CAR-T Cells Therapy: What Cardiovascular Adverse Effects Should We Expect?
نویسندگان
چکیده
Immunotherapy has emerged as a specific treatment, guided by oncologic targets, that given the false impression (to oncologists and hematologists) it had no adverse effects, including cardiovascular complications. Chimeric antigen receptor (CAR) T-cell therapy certainly benefited patients; in contrast, reports of effects have emerged. In this paper, we conducted narrative review conceptual aspects, clinical applicability, cytokine release syndrome, extracardiac AE and, above all, CAR-T cell therapy. [...]
منابع مشابه
Omalizumab: what benefits should we expect?
Chronic spontaneous urticaria (CSU) is a skin disease characterised by wheal appearance, swelling, itching, and painful skin. Omalizumab has been used for CSU treatment demonstrating good efficacy. To investigate the efficacy and safety of omalizumab treatment in CSU patients in real-life practice. A retrospective analysis was performed on 38 patients suffering from CSU who received 300 mg of o...
متن کاملWhat should we expect after the next attack?
A test of any science is its ability to predict events under specified conditions. A test for the psychology represented in this special issue of the American Psychologist is its ability to predict individual and social behavior in the aftermath of a next terror attack. This article draws on that science to make such predictions. These predictions are conditioned on both the nature of the attac...
متن کاملOveryielding and species diversity: what should we expect?
Recent empirical studies have found evidence of increased biomass production ('overyielding') in species mixtures relative to monoculture, but the interpretation of these results remains controversial, in part, because of the lack of a theoretical expectation. Here, we examined the expected frequency and stability of overyielding species mixtures using Lotka-Volterra models of species dynamics ...
متن کاملTight glycemic control: what do we really know, and what should we expect?
Tight glycemic control has engendered large numbers of investigations, with conflicting results. The world has largely embraced intensive insulin as a practice, but applies this therapy with great variability in the manner of glucose control and measurement. The present commentary reviews what we actually know with certainty from this vast sea of literature, and what we can expect looking forward.
متن کاملDesign and development of CAR-T cells for cancer therapy
Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ABC Heart Failure & Cardiomyopathy
سال: 2022
ISSN: ['2764-3107']
DOI: https://doi.org/10.36660/abchf.20230002